BNF for Children 2022-2023 Paediatric Formulary Committee
کتاب افست زبان اصلی بریتیش نشنال فارماکوپه اطفال : چاپ رنگی | کاغذ تحریر
Published jointly by the British Medical Association, Royal Pharmaceutical Society, the Royal College of Paediatrics and Child Health, and the Neonatal and Paediatric Pharmacists Group
The BNF for Children is the first choice for concise medicines information for children. Trusted by healthcare professionals across the world to support confident decision-making at the point of care.
The new edition provides up-to-date guidance on prescribing, dispensing, and administering medicines to children, plus legal and professional guidelines.
Recommendations in the BNF for Children have been constructed on the basis of authoritative sources, emerging evidence, best practice guidelines and advice from a network of paediatric experts. The process is overseen by a paediatric formulary committee.
Extensive content updates in the BNF for Children 2022-2023 edition include:
New monographs for:
Acarizax® [house dust mite extract] for house dust mite allergic rhinitis
Adakveo® [crizanlizumab] for vaso-occlusive crises in sickle-cell disease
Cibinqo® [abrocitinib] for atopic eczema
Dificlir® [fidaxomicin] for Clostridioides difficile infection
Evrysdi® [risdiplam] for 5q spinal muscular atrophy
Fintepla® [fenfluramine] for adjunctive therapy of seizures associated with Dravet syndrome
Givlaari® [givosiran] for acute hepatic porphyria
Keytruda® [pembrolizumab] for classical Hodgkin lymphoma
Koselugo® [selumetinib] for inoperable plexiform neurofibromas in patients with neurofibromatosis type 1
Liraglutide for weight management or type 2 diabetes mellitus
Orladeyo® [berotralstat] for hereditary angioedema
Pradaxa® [dabigatran etexilate] for prophylaxis or treatment of venous thromboembolism
Rinvoq® [upadacitinib] for atopic eczema
Ruconest® [conestat alfa] for hereditary angioedema in patients with C1-esterase inhibitor deficiency
Ryaltris® [mometasone furoate with olopatadine] for allergic rhinitis
Taltz® [ixekizumab] for plaque psoriasis
Ultomiris® [ravulizumab] for atypical haemolytic uraemic syndrome or paroxysmal nocturnal haemoglobinuria
Xarelto® [rivaroxaban] for prophylaxis or treatment of venous thromboembolism
Xeljanz® [tofacitinib] for polyarticular juvenile idiopathic arthritis or juvenile psoriatic arthritis
Xevudy® [sotrovimab] for COVID-19
Xofluza® [baloxavir marboxil] for post-exposure prophylaxis or treatment of influenza
MHRA advice on:
Adrenaline/epinephrine auto-injectors: reminder for prescribers to support safe and effective use
Amiodarone hydrochloride (Cordarone X®): reminder of risks of treatment and need for patient monitoring and supervision
Atezolizumab (Tecentriq®) and other immune-stimulatory anti-cancer drugs: risk of severe cutaneous adverse reactions (SCARs)
Chloral hydrate, cloral betaine (Welldorm®): restriction of paediatric indication
Chloramphenicol eye drops containing borax or boric acid buffers: use in children younger than 2 years
Chloroquine: increased risk of cardiovascular events when used with macrolide antibiotics; reminder of psychiatric reactions
Hydroxychloroquine sulfate: increased risk of cardiovascular events when used with macrolide antibiotics; reminder of psychiatric reactions
Ivacaftor, tezacaftor, elexacaftor (Kaftrio®▼) in combination with ivacaftor (Kalydeco®): risk of serious liver injury; updated advice on liver function testing
Levothyroxine sodium: new prescribing advice for patients who experience symptoms on switching between different levothyroxine products
Metformin hydrochloride: study shows no safety concerns in pregnancy
Oral retinoid medicines: temporary monitoring advice during COVID-19 pandemic
Remdesivir: reporting to the UK COVID-19 Antivirals Pregnancy Registry
Tofacitinib (Xeljanz®): new measures to minimise risk of major adverse cardiovascular events and malignancies
Topical corticosteroids: information on the risk of topical steroid withdrawal reactions
Yellow fever vaccine, live (Stamaril®): new pre-vaccination checklist
Othersignificant changes include updated guidance on:
Aciclovir: important safety information added to highlight different approaches to calculating doses depending on the age of the child
Management of acne
Management of anaphylaxis
Contraceptives, interactions
COVID-19 updated guidance in-line with Public Health England/UK Health Security Agency recommendations, including reports of myocarditis and pericarditis with the Pfizer/BioNTech and Moderna vaccines and update to age range of Pfizer/BioNTech vaccine
Diabetic hyperglycaemic emergencies
Management of acute otitis media
Emergency contraception
Management of Clostridioides difficile infection
Immunisation schedule updated guidance in-line with Public Health England/UK Health Security Agency recommendations, including Bacillus Calmette-Guérin, human papillomavirus, and influenza vaccines and immunisation of neonates
Levetiracetam dosing added for convulsive status epilepticus in children
Malaria prophylaxis in-line with Public Health England recommendations
Miconazole oral gel no longer licensed for treatment of intestinal candidiasis
Preventative migraine treatment
Management of nausea and vomiting during pregnancy
New guidance on management of neonatal bacterial infection
Oral anticoagulants
Paediatric Steroid Treatment Card to support early recognition and treatment of adrenal crisis in children with adrenal insufficiency [British Society for Paediatric Endocrinology and Diabetes]
Chronic pain
Phenobarbital oral solutions and advice from the RCPCH/NPPG
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